The National Nurse-Led Care Consortium (NNCC) has developed an issue brief to provide a comprehensive overview of nurse-managed health centers. The brief highlights the importance of nurse leadership and emphasizes the role of nurse-led care on improved provision of primary care. Uniform Data System (UDS) data from 2016 to 2020, demonstrates a 41% increase in the utilization of nurse practitioners (NP) in comparison to a 15% growth for physicians across health centers. The brief discusses opportunities for health centers to optimize this growth in the NP workforce to improve health care access, population health outcomes, and health equity for communities made vulnerable by social and systemic injustice.